Peripheral Non-Viral MIDGE Vector-Driven Delivery of β-Endorphin in Inflammatory Pain
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چکیده
منابع مشابه
Peripheral non-viral MIDGE vector-driven delivery of β-endorphin in inflammatory pain
BACKGROUND Leukocytes infiltrating inflamed tissue produce and release opioid peptides such as beta-endorphin, which activate opioid receptors on peripheral terminals of sensory nerves resulting in analgesia. Gene therapy is an attractive strategy to enhance continuous production of endogenous opioids. However, classical viral and plasmid vectors for gene delivery are hampered by immunogenicity...
متن کاملβ-Endorphin attenuates collagen-induced arthritis partially by inhibiting peripheral pro-inflammatory mediators.
The classical analgesic pathway of opioids by binding their receptors in the nervous system is well known. However, little is known regarding opioid analgesia through the anti-inflammatory pathway. The present study aimed to investigate the analgesic and anti-inflammatory effect of β-endorphin on inflammatory pain. A rat model of collagen-induced arthritis (CIA) was generated by intradermal inj...
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Topically applied opioids have provided effective analgesia without adverse effects, including tolerance, in adult patients with painful inflammatory conditions. The presumed mechanism of action is by interaction with opioid receptors which are sited on sensory nerve terminals and which may be up-regulated in inflammation. The use of peripherally acting opioids has not been studied in paediatri...
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ژورنال
عنوان ژورنال: Molecular Pain
سال: 2009
ISSN: 1744-8069,1744-8069
DOI: 10.1186/1744-8069-5-72